Thursday, April 12, 2007
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Tuesday, April 10, 2007
The Role of Radiotherapy in the Treatment of Malignant Pleural Mesothelioma
K. Waite and D. Gilligan
Oncology Centre, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK
Radiation therapy for the treatment of malignant pleural mesothelioma has historically been limited by its efficacy. However, the increasing incidence of this tumour and the emergence of new technologies present a number of opportunities and challenges for this treatment modality. Radiotherapy is used to palliate mesothelioma patients with chest wall pain.
Responses of over 60% have been seen, although the duration of response is often disappointing. The optimum dose has not been shown and many of the previous studies were small retrospective studies. An improved response has been seen in several studies where hyperthermia was added to radiotherapy. However, further investigation of this technique, which is not widely available, is required. There has not been any comparison of radiotherapy with chemotherapy in the palliation of patients with malignant pleural mesothelioma.
Prophylactic chest wall radiotherapy to intervention sites successfully reduces the incidence of malignant seeding along the intervention tracts. However, the optimum dose and timing of treatment are not clear. There is no role for radical radiotherapy alone, but the role of radiotherapy as part of multimodality therapy is discussed. There have been studies of intensity-modulated radiotherapy as part of multimodality therapy and this technique needs to be evaluated further.
Oncology Centre, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK
Radiation therapy for the treatment of malignant pleural mesothelioma has historically been limited by its efficacy. However, the increasing incidence of this tumour and the emergence of new technologies present a number of opportunities and challenges for this treatment modality. Radiotherapy is used to palliate mesothelioma patients with chest wall pain.
Responses of over 60% have been seen, although the duration of response is often disappointing. The optimum dose has not been shown and many of the previous studies were small retrospective studies. An improved response has been seen in several studies where hyperthermia was added to radiotherapy. However, further investigation of this technique, which is not widely available, is required. There has not been any comparison of radiotherapy with chemotherapy in the palliation of patients with malignant pleural mesothelioma.
Prophylactic chest wall radiotherapy to intervention sites successfully reduces the incidence of malignant seeding along the intervention tracts. However, the optimum dose and timing of treatment are not clear. There is no role for radical radiotherapy alone, but the role of radiotherapy as part of multimodality therapy is discussed. There have been studies of intensity-modulated radiotherapy as part of multimodality therapy and this technique needs to be evaluated further.
Monday, April 9, 2007
How can asbestos affect my health?
Asbestos mainly affects the lungs and the membrane that surrounds the lungs. Breathing high levels of asbestos fibers for a long time may result in scar-like tissue in the lungs and in the pleural membrane (lining) that surrounds the lung. This disease is called asbestosis and is usually found in workers exposed to asbestos, but not in the general public. People with asbestosis have difficulty breathing, often a cough, and in severe cases heart enlargement. Asbestosis is a serious disease and can eventually lead to disability and death.
Breathing lower levels of asbestos may result in changes called plaques in the pleural membranes. Pleural plaques can occur in workers and sometimes in people living in areas with high environmental levels of asbestos. Effects on breathing from pleural plaques alone are not usually serious, but higher exposure can lead to a thickening of the pleural membrane that may restrict breathing.
Breathing lower levels of asbestos may result in changes called plaques in the pleural membranes. Pleural plaques can occur in workers and sometimes in people living in areas with high environmental levels of asbestos. Effects on breathing from pleural plaques alone are not usually serious, but higher exposure can lead to a thickening of the pleural membrane that may restrict breathing.
Diagnosis of Mesothelioma
The onset of mesothelioma symptoms usually takes a long time. The first symptom is often a constant chest pain. This pain is later accompanies by difficulty breathing due to an accumulation of fluid in the chest. Other symptoms include coughing, fever and weight loss. Mesothelioma can be diagnosed by your doctor with a chest CT-scan.
What Needs to Happen?
After a positive mesothelioma diagnosis, your doctor will discuss the available treatment options. Many newer treatments promise to improve patients quality of life and add several years of life. What may not be explained the that the disease is not a random act of nature, but the result of a dangerous product that was used despite evidence of the harm it would cause. Companies have had to pay workers billions of dollars to compensate them and their families for this wanton disregard of human life and safety.
Will there be a lawsuit?
Most people are reluctant to take legal action. However, Mesothelioma presents a nearly 100% certainty that someone or a company is at fault. If the person's work history can be traced, the likelihood is that a very large settlement awaits the victim. Your attorney can explain the details, but most claims settle out of court very quickly, unlike many other types of cases.
How much will I get?
The amount of the settlements varies greatly, but usually start at half million to several million. The award is based on many factors such as the amount of funds available, the duration and location of the asbestos exposure, the persons overall health. Your attorney will know how to maximize the recovery to get the most compensation for you and your family.
What Needs to Happen?
After a positive mesothelioma diagnosis, your doctor will discuss the available treatment options. Many newer treatments promise to improve patients quality of life and add several years of life. What may not be explained the that the disease is not a random act of nature, but the result of a dangerous product that was used despite evidence of the harm it would cause. Companies have had to pay workers billions of dollars to compensate them and their families for this wanton disregard of human life and safety.
Will there be a lawsuit?
Most people are reluctant to take legal action. However, Mesothelioma presents a nearly 100% certainty that someone or a company is at fault. If the person's work history can be traced, the likelihood is that a very large settlement awaits the victim. Your attorney can explain the details, but most claims settle out of court very quickly, unlike many other types of cases.
How much will I get?
The amount of the settlements varies greatly, but usually start at half million to several million. The award is based on many factors such as the amount of funds available, the duration and location of the asbestos exposure, the persons overall health. Your attorney will know how to maximize the recovery to get the most compensation for you and your family.
Asbestos exposure causes mesothelioma
Although asbestos exposure causes mesothelioma, it has a latency period after exposure that could last 15 to 50 years. This means that someone who worked in a factory with asbestos 40 years ago could be developing mesothelioma now. Anyone who knows they were exposed to loose asbestos fibers should be tested regularly for mesothelioma.
What causes mesothelioma?
Virtually all cases of mesothelioma are related to inhaling of asbestos fibers. There are about 3,000 cases per year (mostly men over the age of 40) and there will be about 300,000 cases before 2030. Mesothelioma usually spreads rapidly through the mesothelial cells to the heart and abdominal organs. The life span is typically 24 months after diagnosis, but it depends on what stage the cancer is detected, the health of the patient and other factors.
What is Mesothelioma?
Mesothelioma is the term used to describe a cancerous tumor that involves the mesothelial cells of an organ. Mesothelial cells are cells that form a protective lining over the lungs, heart and abdominal organs. The most common type of mesothelioma is pleural mesothelioma.
The pleura is a thin membrane found between the lungs and the chest cavity.
It provides a lubricated surface so that the lungs do not rub and chafe against the chest walls.
The pleura is a thin membrane found between the lungs and the chest cavity.
It provides a lubricated surface so that the lungs do not rub and chafe against the chest walls.
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